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Assay Detail

CHEMBL767476

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
In vitro for inhibitory activity against protein kinase C from rat brain
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Protein kinase C (PKC) (CHEMBL2094266)
Type PROTEIN FAMILY
Organism Rattus norvegicus

Publication

Non-glycosidic/non-aminoalkyl-substituted indolocarbazoles as inhibitors of protein kinase C
Kleinschroth J, Hartenstein J, Rudolph C, Schachtele C
Bioorg Med Chem Lett (1993) 3 : 1959 -1964
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 6.80 8.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL388978 STAUROSPORINE 1 8.05
CHEMBL302449 GO-6976 1 7.70
CHEMBL59385 1 7.60
CHEMBL58458 1 7.57
CHEMBL303990 1 7.50
CHEMBL292746 1 7.12
CHEMBL291920 1 7.00
CHEMBL59054 1 7.00
CHEMBL59384 1 6.96
CHEMBL301228 1 6.70
CHEMBL301620 1 6.35
CHEMBL59004 1 6.28
CHEMBL59009 1 6.23
CHEMBL16958 STAUROSPORINONE 1 6.17
CHEMBL299248 1 5.46
CHEMBL294684 1 5.09
CHEMBL61753 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL388978 STAUROSPORINE IC50 = 9.0 nM 8.05
CHEMBL302449 GO-6976 IC50 = 20.0 nM 7.70
CHEMBL59385 IC50 = 25.0 nM 7.60
CHEMBL58458 IC50 = 27.0 nM 7.57
CHEMBL303990 IC50 = 32.0 nM 7.50
CHEMBL292746 IC50 = 75.0 nM 7.12
CHEMBL291920 IC50 = 99.0 nM 7.00
CHEMBL59054 IC50 = 100.0 nM 7.00
CHEMBL59384 IC50 = 110.0 nM 6.96
CHEMBL301228 IC50 = 200.0 nM 6.70
CHEMBL301620 IC50 = 450.0 nM 6.35
CHEMBL59004 IC50 = 520.0 nM 6.28
CHEMBL59009 IC50 = 590.0 nM 6.23
CHEMBL16958 STAUROSPORINONE IC50 = 680.0 nM 6.17
CHEMBL299248 IC50 = 3500.0 nM 5.46
CHEMBL294684 IC50 = 8100.0 nM 5.09
CHEMBL61753 IC50 > 30000.0 nM -