Compound Detail
CHEMBL292746
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL292746 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OYIIOLJNSPALSW-UHFFFAOYSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
364.4
MW (Da)
4.59
ALogP
3
HBA
2
HBD
73.6
PSA (Ų)
0.48
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C (PKC) CHEMBL2094266 | IC50 | 7.12 | 7.12 | 75.0 | 1 |
| cGMP-dependent protein kinase 1 CHEMBL3183 | IC50 | 6.5 | 6.5 | 320.0 | 1 |
| Myosin light chain kinase, smooth muscle CHEMBL3062 | IC50 | 6.3 | 6.3 | 500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C (PKC) | IC50 | = | 75.0 | nM | 7.12 | In vitro for inhibitory activity against protein kinase C from rat brain | - |
| cGMP-dependent protein kinase 1 | IC50 | = | 320.0 | nM | 6.5 | In vitro for inhibitory activity against cGMP-dependent protein kinase from bovi... | - |
| Myosin light chain kinase, smooth muscle | IC50 | = | 500.0 | nM | 6.3 | In vitro for inhibitory activity against myosin light-chain kinase from chicken ... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(01)80995-1 | Protein kinase C (PKC) | 1 |
| - | 10.1016/S0960-894X(01)80995-1 | cAMP-dependent protein kinase catalytic subunit alpha | 1 |
| - | 10.1016/S0960-894X(01)80995-1 | cGMP-dependent protein kinase 1 | 1 |
| - | 10.1016/S0960-894X(01)80995-1 | Myosin light chain kinase, smooth muscle | 1 |
| - | 10.1016/S0960-894X(01)80995-1 | Splenocyte | 1 |
| 28412530 | 10.1016/j.ejmech.2017.04.003 | Protein kinase C beta type | 1 |
| 28412530 | 10.1016/j.ejmech.2017.04.003 | Protein kinase C alpha type | 1 |
Data from ChEMBL 36 via Core Engine