Assay Detail
Binding
CHEMBL769148
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In vitro for inhibitory activity against myosin light-chain kinase from chicken gizzard (M-kinase)
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Myosin light chain kinase, smooth muscle (CHEMBL3062) ↗| Type | SINGLE PROTEIN |
| Organism | Gallus gallus |
Publication
Non-glycosidic/non-aminoalkyl-substituted indolocarbazoles as inhibitors of protein kinase C
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.07 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.00 |
| CHEMBL59384 | — | — | 1 | 7.09 |
| CHEMBL291920 | — | — | 1 | 6.41 |
| CHEMBL303990 | — | — | 1 | 6.36 |
| CHEMBL59385 | — | — | 1 | 6.35 |
| CHEMBL292746 | — | — | 1 | 6.30 |
| CHEMBL59004 | — | — | 1 | 5.96 |
| CHEMBL301228 | — | — | 1 | 5.92 |
| CHEMBL58458 | — | — | 1 | 5.80 |
| CHEMBL59009 | — | — | 1 | 5.75 |
| CHEMBL16958 | STAUROSPORINONE | — | 1 | 5.55 |
| CHEMBL301620 | — | — | 1 | 5.24 |
| CHEMBL302449 | GO-6976 | — | 1 | 5.24 |
| CHEMBL59054 | — | — | 1 | 4.96 |
| CHEMBL61753 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL59384 | — | IC50 | = | 82.0 | nM | 7.09 |
| CHEMBL291920 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL303990 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL59385 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL292746 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL59004 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL301228 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL58458 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL59009 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL16958 | STAUROSPORINONE | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL301620 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL302449 | GO-6976 | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL59054 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL61753 | — | IC50 | > | 10000.0 | nM | - |