Assay Detail
Binding
CHEMBL767489
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Inhibitory activity against partially purified (chicken skeletal muscle) Protein phosphatase 2A
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Muscle tissue |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine-threonine protein phosphatase 2A regulatory subunit (CHEMBL2669) ↗| Type | SINGLE PROTEIN |
| Organism | Gallus gallus |
Publication
Anhydride modified cantharidin analogues: synthesis, inhibition of protein phosphatases 1 and 2A and anticancer activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.06 | 6.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48449 | CANTHARIDIN | 4.0 | 1 | 6.58 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | — | 1 | 6.43 |
| CHEMBL47665 | — | — | 1 | 6.39 |
| CHEMBL48076 | — | — | 1 | 6.35 |
| CHEMBL48010 | — | — | 1 | 6.33 |
| CHEMBL47461 | — | — | 1 | 4.26 |
| CHEMBL45742 | — | — | 1 | - |
| CHEMBL298459 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48449 | CANTHARIDIN | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL47665 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL48076 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL48010 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL47461 | — | IC50 | = | 55000.0 | nM | 4.26 |
| CHEMBL45742 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL298459 | — | IC50 | > | 1000000.0 | nM | - |