Assay Detail
Binding
CHEMBL767490
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Inhibitory concentration against protein phosphatase 2A (PP2A) was determined
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Serine-threonine protein phosphatase 2A regulatory subunit (CHEMBL2669) ↗| Type | SINGLE PROTEIN |
| Organism | Gallus gallus |
Publication
Cantharimides: a new class of modified cantharidin analogues inhibiting protein phosphatases 1 and 2A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.50 | 6.09 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL100935 | — | — | 1 | 6.09 |
| CHEMBL100883 | — | — | 1 | 5.87 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | — | 1 | 5.54 |
| CHEMBL99719 | — | — | 1 | 4.50 |
| CHEMBL319130 | — | — | 1 | - |
| CHEMBL318088 | — | — | 1 | - |
| CHEMBL408609 | — | — | 1 | - |
| CHEMBL102037 | — | — | 1 | - |
| CHEMBL328624 | — | — | 1 | - |
| CHEMBL319542 | — | — | 1 | - |
| CHEMBL316621 | — | — | 1 | - |
| CHEMBL98050 | — | — | 1 | - |
| CHEMBL432193 | — | — | 1 | - |
| CHEMBL316871 | — | — | 1 | - |
| CHEMBL323093 | — | — | 1 | - |
| CHEMBL101983 | — | — | 1 | - |
| CHEMBL98113 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL100935 | — | IC50 | = | 810.0 | nM | 6.09 |
| CHEMBL100883 | — | IC50 | = | 1350.0 | nM | 5.87 |
| CHEMBL8327 | DEMETHYL-CANTHARIDIN | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL99719 | — | IC50 | = | 32000.0 | nM | 4.50 |
| CHEMBL319130 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL318088 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL408609 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL102037 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL328624 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL319542 | — | IC50 | = | 105000.0 | nM | - |
| CHEMBL316621 | — | IC50 | = | 245000.0 | nM | - |
| CHEMBL98050 | — | IC50 | = | 150000.0 | nM | - |
| CHEMBL432193 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL316871 | — | IC50 | = | 157000.0 | nM | - |
| CHEMBL323093 | — | IC50 | = | 112000.0 | nM | - |
| CHEMBL101983 | — | IC50 | > | 1000000.0 | nM | - |
| CHEMBL98113 | — | IC50 | > | 1000000.0 | nM | - |