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Assay Detail

CHEMBL767497

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Prostaglandin G/H synthase in bovine thrombocyte intact cell assay.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 4 — Cell-line / Tissue
Curated By Autocuration

Target

Cyclooxygenase (CHEMBL2096674)
Type PROTEIN FAMILY
Organism Bos taurus

Publication

(6,7-Diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase.
Laufer SA, Augustin J, Dannhardt G, Kiefer W.
J Med Chem (1994) 37 : 1894 -1897
PubMed 8021931 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 18 5.71 7.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL292239 1 7.52
CHEMBL54506 1 7.00
CHEMBL56161 1 7.00
CHEMBL300982 LICOFELONE 2.0 1 6.68
CHEMBL300670 1 6.10
CHEMBL291487 1 6.00
CHEMBL54658 1 5.80
CHEMBL294159 1 5.70
CHEMBL55414 1 5.70
CHEMBL301264 1 5.50
CHEMBL56600 1 5.47
CHEMBL301693 1 5.44
CHEMBL54485 1 5.35
CHEMBL56033 1 4.92
CHEMBL54486 1 4.92
CHEMBL56034 1 4.75
CHEMBL57062 1 4.70
CHEMBL56294 1 4.21

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL292239 IC50 = 30.0 nM 7.52
CHEMBL54506 IC50 = 100.0 nM 7.00
CHEMBL56161 IC50 = 100.0 nM 7.00
CHEMBL300982 LICOFELONE IC50 = 210.0 nM 6.68
CHEMBL300670 IC50 = 800.0 nM 6.10
CHEMBL291487 IC50 = 1000.0 nM 6.00
CHEMBL54658 IC50 = 1600.0 nM 5.80
CHEMBL294159 IC50 = 2000.0 nM 5.70
CHEMBL55414 IC50 = 2000.0 nM 5.70
CHEMBL301264 IC50 = 3200.0 nM 5.50
CHEMBL56600 IC50 = 3400.0 nM 5.47
CHEMBL301693 IC50 = 3600.0 nM 5.44
CHEMBL54485 IC50 = 4500.0 nM 5.35
CHEMBL56033 IC50 = 12000.0 nM 4.92
CHEMBL54486 IC50 = 12000.0 nM 4.92
CHEMBL56034 IC50 = 18000.0 nM 4.75
CHEMBL57062 IC50 = 20000.0 nM 4.70
CHEMBL56294 IC50 = 61000.0 nM 4.21