Assay Detail
Binding
CHEMBL767565
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Inhibition of 3 nM [3H]R5020 binding to progesterone receptor of human T47D cell cytosol
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | T47D |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New progesterone receptor antagonists: 3,3-disubstituted-5-aryloxindoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 6.71 | 7.29 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL333484 | — | — | 1 | 7.29 |
| CHEMBL118861 | — | — | 1 | 7.02 |
| CHEMBL419057 | — | — | 1 | 6.71 |
| CHEMBL117461 | — | — | 1 | 6.64 |
| CHEMBL324115 | — | — | 1 | 6.32 |
| CHEMBL119058 | — | — | 1 | 6.29 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL333484 | — | IC50 | = | 51.0 | nM | 7.29 |
| CHEMBL118861 | — | IC50 | = | 96.0 | nM | 7.02 |
| CHEMBL419057 | — | IC50 | = | 193.0 | nM | 6.71 |
| CHEMBL117461 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL324115 | — | IC50 | = | 477.0 | nM | 6.32 |
| CHEMBL119058 | — | IC50 | = | 509.0 | nM | 6.29 |