Assay Detail
Functional
CHEMBL767669
Review assay metadata, readout intent, target linkage, and publication context from the same page.
5-LO inhibitory activity was determined by inhibition of LTB4 biosynthesis in bovine polymorphonuclear leukocytes (PMNL)
57
Total Activities
57
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Simple analogues of anthralin: unusual specificity of structure and antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 57 | 5.06 | 5.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL123148 | — | — | 1 | 5.70 |
| CHEMBL124440 | ANTHRONE | — | 1 | 5.70 |
| CHEMBL274056 | NAPHTHAZALIN | — | 1 | 5.52 |
| CHEMBL421615 | — | — | 1 | 5.52 |
| CHEMBL123692 | — | — | 1 | 5.40 |
| CHEMBL122022 | — | — | 1 | 5.40 |
| CHEMBL307145 | PYROGALLOL | -1.0 | 1 | 5.40 |
| CHEMBL121693 | — | — | 1 | 5.40 |
| CHEMBL124951 | — | — | 1 | 5.40 |
| CHEMBL123724 | — | — | 1 | 5.40 |
| CHEMBL126105 | — | — | 1 | 5.22 |
| CHEMBL126057 | — | — | 1 | 5.22 |
| CHEMBL125765 | — | — | 1 | 5.22 |
| CHEMBL123787 | — | — | 1 | 5.16 |
| CHEMBL126056 | — | — | 1 | 5.10 |
| CHEMBL125822 | — | — | 1 | 5.10 |
| CHEMBL123326 | — | — | 1 | 5.05 |
| CHEMBL125328 | — | — | 1 | 5.00 |
| CHEMBL333452 | — | — | 1 | 5.00 |
| CHEMBL125592 | — | — | 1 | 4.92 |
| CHEMBL126090 | — | — | 1 | 4.92 |
| CHEMBL123161 | — | — | 1 | 4.89 |
| CHEMBL122192 | EMODIN ANTHRONE | — | 1 | 4.85 |
| CHEMBL43612 | JUGLONE | — | 1 | 4.77 |
| CHEMBL339332 | — | — | 1 | 4.75 |
| CHEMBL124264 | — | — | 1 | 4.70 |
| CHEMBL125175 | — | — | 1 | 4.68 |
| CHEMBL125762 | — | — | 1 | 4.60 |
| CHEMBL421625 | — | — | 1 | 4.57 |
| CHEMBL122386 | — | — | 1 | 4.55 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL123148 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL124440 | ANTHRONE | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL421615 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL274056 | NAPHTHAZALIN | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL123692 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL122022 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL307145 | PYROGALLOL | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL121693 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL124951 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL123724 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL126105 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL126057 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL125765 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL123787 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL125822 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL126056 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL123326 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL125328 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL333452 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL125592 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL126090 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL123161 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL122192 | EMODIN ANTHRONE | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL43612 | JUGLONE | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL339332 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL124264 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL125175 | — | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL125762 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL421625 | — | IC50 | = | 27000.0 | nM | 4.57 |
| CHEMBL122386 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL415019 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL46469 | ANTHRALIN | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL126813 | HARUNGANOL B | IC50 | > | 30000.0 | nM | - |
| CHEMBL125427 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL125254 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL104546 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL273643 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL53418 | DANTHRON | IC50 | > | 30000.0 | nM | - |
| CHEMBL121770 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL125388 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL127993 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL125389 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL286494 | HYPERICIN | IC50 | > | 30000.0 | nM | - |
| CHEMBL332779 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL123886 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL125337 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL123271 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL333179 | ANTHRACENE | IC50 | > | 30000.0 | nM | - |
| CHEMBL412821 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL497001 | ALOIN | IC50 | > | 30000.0 | nM | - |