Assay Detail
Functional
CHEMBL767670
Review assay metadata, readout intent, target linkage, and publication context from the same page.
5-LO inhibitory activity, measured by production of 5-hydroxyeicosatetraenoic acid (5-HETE) and leukotriene B4 (LTB4) in bovine polymorphonuclear leukocytes
42
Total Activities
42
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Antipsoriatic anthrones with modulated redox properties. 4. Synthesis and biological activity of novel 9,10-dihydro-1,8-dihydroxy-9-oxo-2-anthracenecarboxylic and -hydroxamic acids.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 42 | 5.42 | 6.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL440508 | — | — | 1 | 6.40 |
| CHEMBL96598 | — | — | 1 | 6.30 |
| CHEMBL96252 | — | — | 1 | 6.22 |
| CHEMBL96402 | — | — | 1 | 6.22 |
| CHEMBL96073 | — | — | 1 | 6.16 |
| CHEMBL96307 | — | — | 1 | 6.00 |
| CHEMBL96122 | — | — | 1 | 6.00 |
| CHEMBL45410 | — | — | 1 | 5.70 |
| CHEMBL94452 | — | — | 1 | 5.70 |
| CHEMBL96280 | — | — | 1 | 5.70 |
| CHEMBL321114 | — | — | 1 | 5.70 |
| CHEMBL96663 | — | — | 1 | 5.70 |
| CHEMBL96264 | — | — | 1 | 5.52 |
| CHEMBL96566 | — | — | 1 | 5.40 |
| CHEMBL94484 | — | — | 1 | 5.40 |
| CHEMBL96198 | — | — | 1 | 5.40 |
| CHEMBL96929 | — | — | 1 | 5.30 |
| CHEMBL96759 | — | — | 1 | 5.30 |
| CHEMBL96570 | — | — | 1 | 5.30 |
| CHEMBL96311 | — | — | 1 | 5.22 |
| CHEMBL319577 | — | — | 1 | 5.22 |
| CHEMBL94589 | — | — | 1 | 5.22 |
| CHEMBL96716 | — | — | 1 | 5.22 |
| CHEMBL92297 | — | — | 1 | 5.00 |
| CHEMBL96898 | — | — | 1 | 4.89 |
| CHEMBL317835 | — | — | 1 | 4.77 |
| CHEMBL93450 | — | — | 1 | 4.75 |
| CHEMBL431819 | — | — | 1 | 4.72 |
| CHEMBL321113 | — | — | 1 | 4.66 |
| CHEMBL94394 | BUFEXAMAC | 4.0 | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL440508 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL96598 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL96402 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL96252 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL96073 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL96307 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL96122 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL96663 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL321114 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL96280 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL94452 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL45410 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL96264 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL96198 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL94484 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL96566 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL96929 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL96759 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL96570 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL96716 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL94589 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL96311 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL319577 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL92297 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL96898 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL317835 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL93450 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL431819 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL321113 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL94394 | BUFEXAMAC | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL46469 | ANTHRALIN | IC50 | = | 37000.0 | nM | 4.43 |
| CHEMBL96928 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL96945 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL96851 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL44843 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL93818 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL96357 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL94867 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL94516 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL96582 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL96710 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL2114282 | — | IC50 | > | 30000.0 | nM | - |