Assay Detail
Functional
CHEMBL767676
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Test inhibition of LTB4 production in human peripheral blood polymorphonuclear leukocytes (HPMN)
54
Total Activities
53
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Dioxabicyclooctanyl naphthalenenitriles as nonredox 5-lipoxygenase inhibitors: structure-activity relationship study directed toward the improvement of metabolic stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 54 | 8.06 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL339970 | — | — | 1 | 9.00 |
| CHEMBL338461 | — | — | 1 | 9.00 |
| CHEMBL129292 | — | — | 1 | 8.82 |
| CHEMBL131135 | — | — | 1 | 8.70 |
| CHEMBL129018 | — | — | 1 | 8.70 |
| CHEMBL338132 | — | — | 1 | 8.70 |
| CHEMBL99469 | — | — | 1 | 8.70 |
| CHEMBL339993 | — | — | 1 | 8.70 |
| CHEMBL128300 | — | — | 1 | 8.70 |
| CHEMBL128821 | — | — | 1 | 8.70 |
| CHEMBL129478 | — | — | 1 | 8.70 |
| CHEMBL127779 | — | — | 1 | 8.70 |
| CHEMBL97380 | — | — | 1 | 8.52 |
| CHEMBL129056 | — | — | 1 | 8.52 |
| CHEMBL128751 | — | — | 1 | 8.52 |
| CHEMBL16596 | QUIFLAPON | 2.0 | 1 | 8.52 |
| CHEMBL414244 | — | — | 1 | 8.52 |
| CHEMBL129916 | — | — | 1 | 8.52 |
| CHEMBL414375 | — | — | 1 | 8.52 |
| CHEMBL436595 | — | — | 1 | 8.40 |
| CHEMBL434057 | — | — | 1 | 8.40 |
| CHEMBL129167 | — | — | 1 | 8.40 |
| CHEMBL340795 | — | — | 1 | 8.30 |
| CHEMBL129253 | — | — | 1 | 8.22 |
| CHEMBL128238 | — | — | 2 | 8.15 |
| CHEMBL340737 | — | — | 1 | 8.15 |
| CHEMBL128143 | — | — | 1 | 8.10 |
| CHEMBL128666 | — | — | 1 | 8.05 |
| CHEMBL128716 | — | — | 1 | 8.00 |
| CHEMBL20403 | ZD-2138 | — | 1 | 8.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL339970 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL338461 | — | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL129292 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL129018 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL99469 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL131135 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL339993 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL338132 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL128300 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL128821 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL127779 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL129478 | — | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL414375 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL16596 | QUIFLAPON | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL129056 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL128751 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL97380 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL129916 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL414244 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL434057 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL129167 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL436595 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL340795 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL129253 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL340737 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL128238 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL128143 | — | IC50 | = | 8.0 | nM | 8.10 |
| CHEMBL128666 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL128716 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL20403 | ZD-2138 | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL340333 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL340957 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL420145 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL128105 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL129517 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL128238 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL340805 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL421447 | — | IC50 | = | 26.0 | nM | 7.58 |
| CHEMBL128094 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL129669 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL129351 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL129566 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL130963 | — | IC50 | = | 41.0 | nM | 7.39 |
| CHEMBL339953 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL338867 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL338489 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL338549 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL129318 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL93 | ZILEUTON | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL129258 | — | IC50 | > | 700.0 | nM | - |