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Assay Detail

CHEMBL767703

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of partially purified recombinant human calcium sensitive protein kinase C alpha
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Protein kinase C alpha type (CHEMBL299)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Synthesis and protein kinase inhibitory activity of balanol analogues with modified benzophenone subunits.
Lampe JW, Biggers CK, Defauw JM, Foglesong RJ, Hall SE, Heerding JM, Hollinshead SP, Hu H, Hughes PF, Jagdmann GE, Johnson MG, Lai YS, Lowden CT, Lynch MP, Mendoza JS, Murphy MM, Wilson JW, Ballas LM, Carter K, Darges JW, Davis JE, Hubbard FR, Stamper ML.
J Med Chem (2002) 45 : 2624 -2643
PubMed 12036372 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 39 5.60 7.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL265559 1 7.66
CHEMBL48636 1 7.40
CHEMBL89648 1 7.17
CHEMBL312846 1 7.00
CHEMBL89384 1 6.47
CHEMBL91126 1 6.37
CHEMBL89833 1 6.34
CHEMBL88749 1 6.30
CHEMBL328747 1 6.07
CHEMBL89210 1 5.66
CHEMBL90330 1 5.58
CHEMBL89355 1 5.44
CHEMBL89280 1 5.43
CHEMBL89639 1 5.25
CHEMBL421539 1 5.11
CHEMBL433175 1 5.00
CHEMBL89591 1 4.96
CHEMBL86680 1 4.75
CHEMBL91541 1 4.60
CHEMBL327994 1 4.51
CHEMBL433361 1 4.47
CHEMBL88533 1 4.43
CHEMBL88812 1 4.37
CHEMBL88466 1 4.01
CHEMBL88454 1 -
CHEMBL89191 1 -
CHEMBL329437 1 -
CHEMBL313814 1 -
CHEMBL85129 1 -
CHEMBL329178 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL265559 IC50 = 22.0 nM 7.66
CHEMBL48636 IC50 = 40.0 nM 7.40
CHEMBL89648 IC50 = 67.0 nM 7.17
CHEMBL312846 IC50 = 100.0 nM 7.00
CHEMBL89384 IC50 = 340.0 nM 6.47
CHEMBL91126 IC50 = 430.0 nM 6.37
CHEMBL89833 IC50 = 460.0 nM 6.34
CHEMBL88749 IC50 = 500.0 nM 6.30
CHEMBL328747 IC50 = 860.0 nM 6.07
CHEMBL89210 IC50 = 2200.0 nM 5.66
CHEMBL90330 IC50 = 2600.0 nM 5.58
CHEMBL89355 IC50 = 3600.0 nM 5.44
CHEMBL89280 IC50 = 3700.0 nM 5.43
CHEMBL89639 IC50 = 5600.0 nM 5.25
CHEMBL421539 IC50 = 7800.0 nM 5.11
CHEMBL433175 IC50 = 10000.0 nM 5.00
CHEMBL89591 IC50 = 11000.0 nM 4.96
CHEMBL86680 IC50 = 18000.0 nM 4.75
CHEMBL91541 IC50 = 25000.0 nM 4.60
CHEMBL327994 IC50 = 31000.0 nM 4.51
CHEMBL433361 IC50 = 34000.0 nM 4.47
CHEMBL88533 IC50 = 37000.0 nM 4.43
CHEMBL88812 IC50 = 43000.0 nM 4.37
CHEMBL88466 IC50 = 97000.0 nM 4.01
CHEMBL91932 IC50 > 50000.0 nM -
CHEMBL91412 IC50 > 150000.0 nM -
CHEMBL313902 IC50 > 50000.0 nM -
CHEMBL313550 IC50 > 150000.0 nM -
CHEMBL315545 IC50 > 50000.0 nM -
CHEMBL316088 IC50 > 50000.0 nM -
CHEMBL88962 IC50 > 150000.0 nM -
CHEMBL88848 IC50 > 150000.0 nM -
CHEMBL87075 IC50 > 50000.0 nM -
CHEMBL329178 IC50 > 50000.0 nM -
CHEMBL85129 IC50 > 50000.0 nM -
CHEMBL313814 IC50 > 5000.0 nM -
CHEMBL329437 IC50 > 150000.0 nM -
CHEMBL89191 IC50 > 150000.0 nM -
CHEMBL88454 IC50 > 150000.0 nM -