Assay Detail
Binding
CHEMBL767705
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Inhibitory activity against protein kinase C alpha tyrosine kinase.
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Use of a pharmacophore model for the design of EGF-R tyrosine kinase inhibitors: 4-(phenylamino)pyrazolo[3,4-d]pyrimidines.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.29 | 6.25 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL121954 | — | — | 1 | 6.25 |
| CHEMBL332882 | — | — | 1 | 5.82 |
| CHEMBL118130 | — | — | 1 | 5.73 |
| CHEMBL332765 | — | — | 1 | 5.54 |
| CHEMBL332906 | — | — | 1 | 5.44 |
| CHEMBL120319 | — | — | 1 | 5.42 |
| CHEMBL119982 | — | — | 1 | 5.35 |
| CHEMBL120979 | — | — | 1 | 5.33 |
| CHEMBL120069 | — | — | 1 | 5.33 |
| CHEMBL333038 | — | — | 1 | 5.23 |
| CHEMBL332333 | — | — | 1 | 5.16 |
| CHEMBL121260 | — | — | 1 | 5.11 |
| CHEMBL121796 | — | — | 1 | 5.00 |
| CHEMBL122411 | — | — | 1 | 4.72 |
| CHEMBL122068 | — | — | 1 | 4.62 |
| CHEMBL121190 | — | — | 1 | 4.62 |
| CHEMBL122182 | — | — | 1 | - |
| CHEMBL29197 | — | — | 1 | - |
| CHEMBL119977 | — | — | 1 | - |
| CHEMBL120703 | — | — | 1 | - |
| CHEMBL334026 | — | — | 1 | - |
| CHEMBL420885 | — | — | 1 | - |
| CHEMBL123189 | — | — | 1 | - |
| CHEMBL332612 | — | — | 1 | - |
| CHEMBL332971 | — | — | 1 | - |
| CHEMBL333231 | — | — | 1 | - |
| CHEMBL331906 | — | — | 1 | - |
| CHEMBL122245 | — | — | 1 | - |
| CHEMBL122243 | — | — | 1 | - |
| CHEMBL118904 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL121954 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL332882 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL118130 | — | IC50 | = | 1850.0 | nM | 5.73 |
| CHEMBL332765 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL332906 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL120319 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL119982 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL120979 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL120069 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL333038 | — | IC50 | = | 5900.0 | nM | 5.23 |
| CHEMBL332333 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL121260 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL121796 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL122411 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL122068 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL121190 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL122182 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL29197 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL119977 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL120703 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL334026 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL420885 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL123189 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL332612 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL332971 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL333231 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL331906 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL122245 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL122243 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL118904 | — | IC50 | > | 10000.0 | nM | - |