Assay Detail
Binding
CHEMBL767828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Prostaglandin G/H synthase 1 (COX-1).
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
New cyclooxygenase-2/5-lipoxygenase inhibitors. 2. 7-tert-butyl-2,3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations of the dihydrobenzofuran ring.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 5.64 | 7.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL13920 | — | — | 1 | 7.22 |
| CHEMBL13980 | — | — | 1 | 7.02 |
| CHEMBL13878 | TEBUFELONE | 2.0 | 1 | 6.60 |
| CHEMBL276800 | — | — | 1 | 6.40 |
| CHEMBL14767 | — | — | 1 | 5.82 |
| CHEMBL15039 | — | — | 1 | 5.70 |
| CHEMBL13661 | — | — | 1 | 5.70 |
| CHEMBL521 | IBUPROFEN | 4.0 | 1 | 5.52 |
| CHEMBL279166 | — | — | 1 | 5.30 |
| CHEMBL13623 | — | — | 1 | 5.16 |
| CHEMBL15058 | — | — | 1 | 4.70 |
| CHEMBL15014 | — | — | 1 | 4.70 |
| CHEMBL14735 | — | — | 1 | 4.60 |
| CHEMBL274893 | SC-57666 | — | 1 | 4.52 |
| CHEMBL279550 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL13920 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL13980 | — | IC50 | = | 95.0 | nM | 7.02 |
| CHEMBL13878 | TEBUFELONE | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL276800 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL14767 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL15039 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL13661 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL521 | IBUPROFEN | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL279166 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL13623 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL15058 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL15014 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL14735 | — | IC50 | = | 25000.0 | nM | 4.60 |
| CHEMBL274893 | SC-57666 | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL279550 | — | IC50 | > | 100000.0 | nM | - |