Assay Detail
Functional
CHEMBL767838
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration of test compound required to inhibit 50% LTB4-induced degranulation of human PMNs
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 1 — Organism |
| Curated By | Intermediate |
Publication
(E)-3-[[[[6-(2-carboxyethenyl)-5-[[8-(4- methoxyphenyl)octyl]oxy]-2-pyridinyl]-methyl]thio]methyl]benzoic acid and related compounds: high affinity leukotriene B4 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.03 | 6.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL325773 | — | — | 1 | 6.72 |
| CHEMBL422598 | — | — | 1 | 6.57 |
| CHEMBL325637 | — | — | 1 | 6.37 |
| CHEMBL112707 | — | — | 1 | 6.30 |
| CHEMBL112972 | — | — | 1 | 6.11 |
| CHEMBL115362 | — | — | 1 | 6.00 |
| CHEMBL325643 | — | — | 1 | 6.00 |
| CHEMBL115658 | — | — | 1 | 5.77 |
| CHEMBL112169 | — | — | 1 | 5.58 |
| CHEMBL326192 | — | — | 1 | 5.50 |
| CHEMBL115040 | — | — | 1 | 5.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL325773 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL422598 | — | IC50 | = | 271.0 | nM | 6.57 |
| CHEMBL325637 | — | IC50 | = | 426.0 | nM | 6.37 |
| CHEMBL112707 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL112972 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL115362 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL325643 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL115658 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL112169 | — | IC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL326192 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL115040 | — | IC50 | = | 3800.0 | nM | 5.42 |