Assay Detail
Binding
CHEMBL767990
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Inhibition of rat brain protein kinase A(PKA) in 1%DMSO
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Target
cAMP-dependent protein kinase catalytic subunit alpha (CHEMBL3390) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.45 | 5.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266487 | RO-316233 | — | 1 | 5.51 |
| CHEMBL52128 | — | — | 1 | 5.47 |
| CHEMBL51758 | — | — | 1 | 5.37 |
| CHEMBL301389 | — | — | 1 | - |
| CHEMBL54209 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266487 | RO-316233 | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL52128 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL51758 | — | IC50 | = | 4300.0 | nM | 5.37 |
| CHEMBL301389 | — | IC50 | - | nM | - | |
| CHEMBL54209 | — | IC50 | - | nM | - |