Compound Detail
CHEMBL54209
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL54209 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LHGRZBUIYQSMLQ-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
316.4
MW (Da)
3.05
ALogP
3
HBA
1
HBD
51.1
PSA (Ų)
0.74
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein kinase C (PKC) CHEMBL2094266 | IC50 | 6.22 | 6.1 | 600.0 | 2 |
| Protein kinase C gamma type CHEMBL3604 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein kinase C (PKC) | IC50 | = | 600.0 | nM | 6.22 | Inhibition of rat brain protein kinase C(PKC) in 1%DMSO. | 1732526 |
| Protein kinase C gamma type | IC50 | = | 1000.0 | nM | 6.0 | Inhibition of rat brain protein kinase C (PKC) with ATP and histone as substrate... | 1732526 |
| Protein kinase C (PKC) | IC50 | = | 1040.0 | nM | 5.98 | Inhibition of rat brain protein kinase C(PKC) in 10%DMSO. | 1732526 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 1732526 | 10.1021/jm00079a024 | Unchecked | 2 |
| 1732526 | 10.1021/jm00079a024 | Protein kinase C (PKC) | 2 |
| 1732526 | 10.1021/jm00079a024 | cAMP-dependent protein kinase catalytic subunit alpha | 2 |
| 1732526 | 10.1021/jm00079a024 | Protein kinase C gamma type | 1 |
Data from ChEMBL 36 via Core Engine