Assay Detail
Binding
CHEMBL769177
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Inhibition of rat brain protein kinase C(PKC) in 1%DMSO.
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.05 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | — | 1 | 8.52 |
| CHEMBL51758 | — | — | 1 | 7.16 |
| CHEMBL52128 | — | — | 1 | 7.10 |
| CHEMBL266487 | RO-316233 | — | 1 | 7.00 |
| CHEMBL301515 | — | — | 1 | 6.92 |
| CHEMBL301389 | — | — | 1 | 6.40 |
| CHEMBL54209 | — | — | 1 | 6.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL388978 | STAUROSPORINE | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL51758 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL52128 | — | IC50 | = | 80.0 | nM | 7.10 |
| CHEMBL266487 | RO-316233 | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL301515 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL301389 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL54209 | — | IC50 | = | 600.0 | nM | 6.22 |