Assay Detail
Functional
CHEMBL768143
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Antagonistic activity against hPR in co-transfected CV-1 cell
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g] quinolinone.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 6.30 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL163425 | — | — | 1 | 6.82 |
| CHEMBL350932 | — | — | 1 | 6.77 |
| CHEMBL165803 | — | — | 1 | 6.42 |
| CHEMBL423620 | — | — | 1 | 6.37 |
| CHEMBL351447 | — | — | 1 | 6.14 |
| CHEMBL351465 | — | — | 1 | 6.12 |
| CHEMBL161892 | — | — | 1 | 6.00 |
| CHEMBL162569 | — | — | 1 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL163425 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL350932 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL165803 | — | IC50 | = | 380.0 | nM | 6.42 |
| CHEMBL423620 | — | IC50 | = | 430.0 | nM | 6.37 |
| CHEMBL351447 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL351465 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL161892 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL162569 | — | IC50 | = | 1900.0 | nM | 5.72 |