Assay Detail
Functional
CHEMBL768144
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Antagonistic activity was determined in Human progesterone receptor(hPR) of CV-1 cells in cotransfection assay.
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Cell Type | CV-1 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
5-Aryl-1,2-dihydrochromeno[3,4-f]quinolines: a novel class of nonsteroidal human progesterone receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 6.39 | 7.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL102179 | — | — | 1 | 7.27 |
| CHEMBL101852 | — | — | 1 | 7.15 |
| CHEMBL103468 | — | — | 1 | 6.98 |
| CHEMBL320411 | — | — | 1 | 6.88 |
| CHEMBL321584 | — | — | 1 | 6.82 |
| CHEMBL103237 | — | — | 1 | 6.82 |
| CHEMBL102403 | — | — | 1 | 6.60 |
| CHEMBL101914 | — | — | 1 | 6.54 |
| CHEMBL323324 | — | — | 1 | 6.47 |
| CHEMBL286595 | — | — | 1 | 6.22 |
| CHEMBL317921 | — | — | 1 | 6.14 |
| CHEMBL320690 | — | — | 1 | 6.03 |
| CHEMBL101907 | — | — | 1 | 5.96 |
| CHEMBL430855 | — | — | 1 | 5.95 |
| CHEMBL102602 | — | — | 1 | 5.92 |
| CHEMBL103232 | — | — | 1 | 5.50 |
| CHEMBL320423 | — | — | 1 | 5.34 |
| CHEMBL102541 | — | — | 1 | - |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | 4.0 | 1 | - |
| CHEMBL102720 | — | — | 1 | - |
| CHEMBL102754 | — | — | 1 | - |
| CHEMBL103 | PROGESTERONE | 4.0 | 1 | - |
| CHEMBL103092 | — | — | 1 | - |
| CHEMBL318513 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL102179 | — | IC50 | = | 54.0 | nM | 7.27 |
| CHEMBL101852 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL103468 | — | IC50 | = | 105.0 | nM | 6.98 |
| CHEMBL320411 | — | IC50 | = | 132.0 | nM | 6.88 |
| CHEMBL321584 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL103237 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL102403 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL101914 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL323324 | — | IC50 | = | 342.0 | nM | 6.47 |
| CHEMBL286595 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL317921 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL320690 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL101907 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL430855 | — | IC50 | = | 1136.0 | nM | 5.95 |
| CHEMBL102602 | — | IC50 | = | 1207.0 | nM | 5.92 |
| CHEMBL103232 | — | IC50 | = | 3138.0 | nM | 5.50 |
| CHEMBL320423 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL102541 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL717 | MEDROXYPROGESTERONE ACETATE | IC50 | < | 10000.0 | nM | - |
| CHEMBL102720 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL102754 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL103 | PROGESTERONE | IC50 | < | 10000.0 | nM | - |
| CHEMBL103092 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL318513 | — | IC50 | > | 10000.0 | nM | - |