Assay Detail
Binding
CHEMBL768149
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Inhibitory concentration against protein phosphatase 2A was determined
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine-threonine protein phosphatase 2A regulatory subunit (CHEMBL2669) ↗| Type | SINGLE PROTEIN |
| Organism | Gallus gallus |
Publication
Cantharimides: a new class of modified cantharidin analogues inhibiting protein phosphatases 1 and 2A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.38 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48449 | CANTHARIDIN | 4.0 | 1 | 6.44 |
| CHEMBL47665 | — | — | 1 | 6.39 |
| CHEMBL48076 | — | — | 1 | 6.35 |
| CHEMBL48010 | — | — | 1 | 6.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48449 | CANTHARIDIN | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL47665 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL48076 | — | IC50 | = | 450.0 | nM | 6.35 |
| CHEMBL48010 | — | IC50 | = | 470.0 | nM | 6.33 |