Assay Detail
Binding
CHEMBL768161
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Inhibitory concentration against protein phosphatase 2A (PP2A) using pNPP assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (CHEMBL3862) ↗| Type | SINGLE PROTEIN |
| Organism | Bos taurus |
Publication
Microcystin analogues comprised only of Adda and a single additional amino acid retain moderate activity as PP1/PP2A inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 6.23 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL421377 | — | — | 1 | 8.52 |
| CHEMBL318253 | — | — | 1 | 5.16 |
| CHEMBL318666 | — | — | 1 | 5.00 |
| CHEMBL318434 | — | — | 1 | - |
| CHEMBL100880 | — | — | 1 | - |
| CHEMBL100033 | — | — | 1 | - |
| CHEMBL98661 | — | — | 1 | - |
| CHEMBL317292 | — | — | 1 | - |
| CHEMBL97984 | — | — | 1 | - |
| CHEMBL99251 | — | — | 1 | - |
| CHEMBL101402 | — | — | 1 | - |
| CHEMBL316507 | — | — | 1 | - |
| CHEMBL318677 | — | — | 1 | - |
| CHEMBL99014 | — | — | 1 | - |
| CHEMBL97878 | — | — | 1 | - |
| CHEMBL99826 | — | — | 1 | - |
| CHEMBL98309 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL421377 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL318253 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL318666 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL318434 | — | IC50 | > | 39000.0 | nM | - |
| CHEMBL100880 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL100033 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL98661 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL317292 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL97984 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL99251 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL101402 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL316507 | — | IC50 | > | 25000.0 | nM | - |
| CHEMBL318677 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL99014 | — | IC50 | > | 63000.0 | nM | - |
| CHEMBL97878 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL99826 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL98309 | — | IC50 | > | 100000.0 | nM | - |