Assay Detail
Binding
CHEMBL768164
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Inhibition of protein phosphatase 2A (PP2A) was determined by standard phosphorylase a inhibition assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein phosphatase 2A activator (CHEMBL2505) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The selective inhibition of phosphatases by natural toxins: the anhydride domain of tautomycin is not a primary factor in controlling PP1/PP2A selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.05 | 6.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL40248 | — | — | 1 | 6.30 |
| CHEMBL295239 | — | — | 1 | 5.40 |
| CHEMBL505512 | TAUTOMYCIN | — | 1 | 5.03 |
| CHEMBL40247 | — | — | 1 | 4.54 |
| CHEMBL295238 | — | — | 1 | 4.00 |
| CHEMBL40659 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL40248 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL295239 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL505512 | TAUTOMYCIN | IC50 | = | 9400.0 | nM | 5.03 |
| CHEMBL40247 | — | IC50 | = | 29000.0 | nM | 4.54 |
| CHEMBL295238 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL40659 | — | IC50 | = | 300000.0 | nM | - |