Assay Detail
Functional
CHEMBL768216
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Inhibition of RKO tumor cell proliferation
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RKO |
| Confidence | 1 — Organism |
| Curated By | Expert |
Publication
Oxindole-based inhibitors of cyclin-dependent kinase 2 (CDK2): design, synthesis, enzymatic activities, and X-ray crystallographic analysis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 6.02 | 6.41 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL409892 | GW305178X | — | 1 | 6.41 |
| CHEMBL1964245 | — | — | 1 | 6.23 |
| CHEMBL1964242 | — | — | 1 | 6.19 |
| CHEMBL269883 | GW416981X | — | 1 | 6.05 |
| CHEMBL1964244 | — | — | 1 | 6.04 |
| CHEMBL1964260 | — | — | 1 | 6.02 |
| CHEMBL391229 | — | — | 1 | 5.96 |
| CHEMBL271136 | — | — | 1 | 5.89 |
| CHEMBL411426 | — | — | 1 | 5.85 |
| CHEMBL1964250 | — | — | 1 | 5.82 |
| CHEMBL1276446 | — | — | 1 | 5.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL409892 | GW305178X | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL1964245 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL1964242 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL269883 | GW416981X | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL1964244 | — | IC50 | = | 910.0 | nM | 6.04 |
| CHEMBL1964260 | — | IC50 | = | 950.0 | nM | 6.02 |
| CHEMBL391229 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL271136 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL411426 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL1964250 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL1276446 | — | IC50 | = | 1700.0 | nM | 5.77 |