Assay Detail
Binding
CHEMBL768410
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory effect against protein-tyrosine phosphatase Lar, using p-nitrophenyl phosphate as substrate at pH 5.5.
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Receptor-type tyrosine-protein phosphatase F (CHEMBL3521) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and SAR of a novel selective and orally bioavailable nonpeptide classical competitive inhibitor class of protein-tyrosine phosphatase 1B.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 24 | 4.18 | 4.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL138257 | — | — | 1 | 4.30 |
| CHEMBL336435 | — | — | 1 | 4.30 |
| CHEMBL138575 | — | — | 1 | 4.05 |
| CHEMBL137867 | — | — | 1 | 4.05 |
| CHEMBL337326 | — | — | 1 | - |
| CHEMBL336879 | — | — | 1 | - |
| CHEMBL139923 | — | — | 1 | - |
| CHEMBL139050 | — | — | 1 | - |
| CHEMBL139590 | — | — | 1 | - |
| CHEMBL423546 | — | — | 1 | - |
| CHEMBL336908 | — | — | 1 | - |
| CHEMBL344412 | — | — | 1 | - |
| CHEMBL341806 | — | — | 1 | - |
| CHEMBL141481 | — | — | 1 | - |
| CHEMBL138406 | — | — | 1 | - |
| CHEMBL337132 | — | — | 1 | - |
| CHEMBL138152 | — | — | 1 | - |
| CHEMBL138151 | — | — | 1 | - |
| CHEMBL140929 | — | — | 1 | - |
| CHEMBL138713 | — | — | 1 | - |
| CHEMBL139489 | — | — | 1 | - |
| CHEMBL138806 | — | — | 1 | - |
| CHEMBL342612 | — | — | 1 | - |
| CHEMBL342478 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL138257 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL336435 | — | Ki | = | 50000.0 | nM | 4.30 |
| CHEMBL138575 | — | Ki | = | 90000.0 | nM | 4.05 |
| CHEMBL137867 | — | Ki | = | 90000.0 | nM | 4.05 |
| CHEMBL337326 | — | Ki | = | 2000000.0 | nM | - |
| CHEMBL336879 | — | Ki | = | 2000000.0 | nM | - |
| CHEMBL139923 | — | Ki | = | 160000.0 | nM | - |
| CHEMBL139050 | — | Ki | = | 2000000.0 | nM | - |
| CHEMBL139590 | — | Ki | = | 113000.0 | nM | - |
| CHEMBL423546 | — | Ki | = | 110000.0 | nM | - |
| CHEMBL336908 | — | Ki | = | 420000.0 | nM | - |
| CHEMBL344412 | — | Ki | = | 700000.0 | nM | - |
| CHEMBL341806 | — | Ki | = | 550000.0 | nM | - |
| CHEMBL141481 | — | Ki | = | 165000.0 | nM | - |
| CHEMBL138406 | — | Ki | = | 2000000.0 | nM | - |
| CHEMBL337132 | — | Ki | = | 2000000.0 | nM | - |
| CHEMBL138152 | — | Ki | = | 410000.0 | nM | - |
| CHEMBL138151 | — | Ki | = | 400000.0 | nM | - |
| CHEMBL140929 | — | Ki | = | 2000000.0 | nM | - |
| CHEMBL138713 | — | Ki | = | 2000000.0 | nM | - |
| CHEMBL139489 | — | Ki | = | 900000.0 | nM | - |
| CHEMBL138806 | — | Ki | = | 360000.0 | nM | - |
| CHEMBL342612 | — | Ki | = | 2000000.0 | nM | - |
| CHEMBL342478 | — | Ki | = | 450000.0 | nM | - |