Assay Detail
Binding
CHEMBL768472
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Inhibitory activity against protein farnesyltransferase.
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Novel tricyclic aminoacetyl and sulfonamide inhibitors of Ras farnesyl protein transferase
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 32 | 5.36 | 6.18 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL100302 | — | — | 1 | 6.18 |
| CHEMBL101100 | — | — | 1 | 6.00 |
| CHEMBL329983 | — | — | 1 | 6.00 |
| CHEMBL101603 | — | — | 1 | 5.92 |
| CHEMBL316890 | — | — | 1 | 5.72 |
| CHEMBL318211 | — | — | 1 | 5.72 |
| CHEMBL317144 | — | — | 1 | 5.70 |
| CHEMBL318268 | — | — | 1 | 5.52 |
| CHEMBL100738 | — | — | 1 | 5.44 |
| CHEMBL322847 | — | — | 1 | 5.34 |
| CHEMBL318840 | — | — | 1 | 5.33 |
| CHEMBL328427 | — | — | 1 | 5.32 |
| CHEMBL327507 | — | — | 1 | 5.32 |
| CHEMBL100288 | — | — | 1 | 5.28 |
| CHEMBL329519 | — | — | 1 | 5.20 |
| CHEMBL323298 | — | — | 1 | 5.17 |
| CHEMBL444325 | — | — | 1 | 5.09 |
| CHEMBL101936 | — | — | 1 | 5.08 |
| CHEMBL432011 | — | — | 1 | 5.07 |
| CHEMBL318886 | — | — | 1 | 5.06 |
| CHEMBL421576 | — | — | 1 | 5.02 |
| CHEMBL317427 | — | — | 1 | 4.97 |
| CHEMBL316888 | — | — | 1 | 4.94 |
| CHEMBL101782 | — | — | 1 | 4.89 |
| CHEMBL316889 | — | — | 1 | 4.65 |
| CHEMBL431227 | — | — | 1 | - |
| CHEMBL318189 | — | — | 1 | - |
| CHEMBL431622 | — | — | 1 | - |
| CHEMBL101465 | — | — | 1 | - |
| CHEMBL317845 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL100302 | — | IC50 | = | 660.0 | nM | 6.18 |
| CHEMBL101100 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL329983 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL101603 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL316890 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL318211 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL317144 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL318268 | — | IC50 | = | 3050.0 | nM | 5.52 |
| CHEMBL100738 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL322847 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL318840 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL328427 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL327507 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL100288 | — | IC50 | = | 5200.0 | nM | 5.28 |
| CHEMBL329519 | — | IC50 | = | 6290.0 | nM | 5.20 |
| CHEMBL323298 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL444325 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL101936 | — | IC50 | = | 8400.0 | nM | 5.08 |
| CHEMBL432011 | — | IC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL318886 | — | IC50 | = | 8800.0 | nM | 5.06 |
| CHEMBL421576 | — | IC50 | = | 9600.0 | nM | 5.02 |
| CHEMBL317427 | — | IC50 | = | 10600.0 | nM | 4.97 |
| CHEMBL316888 | — | IC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL101782 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL316889 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL431227 | — | IC50 | > | 12000.0 | nM | - |
| CHEMBL318189 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL431622 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL101465 | — | IC50 | > | 11000.0 | nM | - |
| CHEMBL317845 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL101570 | — | IC50 | > | 12000.0 | nM | - |
| CHEMBL102085 | — | IC50 | > | 12000.0 | nM | - |