Compound Detail
CHEMBL100302
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O=C(CN1C(=O)c2ccccc2C1=O)N1CCC(=C2c3ccc(Cl)cc3CCc3cccnc32)CC1
Basic Information
| ChEMBL ID | CHEMBL100302 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NWJZXJKHQUFLNQ-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
498.0
MW (Da)
4.55
ALogP
4
HBA
0
HBD
70.6
PSA (Ų)
0.49
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.18
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 6.18 | 6.18 | 660.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 660.0 | nM | 6.18 | Inhibitory activity against protein farnesyltransferase. | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/S0960-894X(96)00558-6 | Protein farnesyltransferase | 1 |
Data from ChEMBL 36 via Core Engine