Assay Detail
Binding
CHEMBL768492
Review assay metadata, readout intent, target linkage, and publication context from the same page.
The compound was evaluated for its binding affinity against PAF receptor in rabbit platelet
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Oryctolagus cuniculus |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Platelet-activating factor receptor (CHEMBL5136) ↗| Type | SINGLE PROTEIN |
| Organism | Cavia porcellus |
Publication
Discovery and evaluation of a series of 3-acylindole imidazopyridine platelet-activating factor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 3 | 8.85 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL322832 | LEXIPAFANT | 2.0 | 1 | 9.40 |
| CHEMBL369225 | — | — | 1 | 8.74 |
| CHEMBL317090 | — | — | 1 | 8.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL322832 | LEXIPAFANT | Ki | = | 0.4 | nM | 9.40 |
| CHEMBL369225 | — | Ki | = | 1.8 | nM | 8.74 |
| CHEMBL317090 | — | Ki | = | 3.8 | nM | 8.42 |