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Assay Detail

CHEMBL768499

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of [3H]phorbol-12,13-dibutyrate binding to PK-C
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

Protein kinase C alpha type (CHEMBL299)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Conformationally constrained analogues of diacylglycerol. 5. 2,5-Dideoxy-3-O-tetradecanoyl-D-galactono-1,4-lactone: A superior homologue of 3-O-tetradecanoyl-2-deoxy-L-ribonolactone with PK-C binding affinity.
Sharma R, Marquez VE, Milne GW, Lewin NE, Blumberg PM
Bioorg Med Chem Lett (1993) 3 : 1993 -1998
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 1 5.60 5.60

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL276429 1 5.60

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL276429 Ki = 2500.0 nM 5.60