Assay Detail
Binding
CHEMBL768512
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Displacement of [3H-20]-phorbol-12-13-dibutyrate from bovine brain protein kinase C alpha
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bos taurus |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Conformationally constrained analogues of diacylglycerol. 9.1 the effect of side-chain orientation on the protein kinase C (PK-C) binding affinity of -lactones
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 6.04 | 6.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL78799 | — | — | 1 | 6.70 |
| CHEMBL422215 | — | — | 1 | 6.70 |
| CHEMBL13306 | — | — | 1 | 6.52 |
| CHEMBL79376 | — | — | 1 | 5.89 |
| CHEMBL81971 | — | — | 1 | 5.72 |
| CHEMBL78679 | — | — | 1 | 4.69 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL78799 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL422215 | — | Ki | = | 200.0 | nM | 6.70 |
| CHEMBL13306 | — | Ki | = | 300.0 | nM | 6.52 |
| CHEMBL79376 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL81971 | — | Ki | = | 1900.0 | nM | 5.72 |
| CHEMBL78679 | — | Ki | = | 20500.0 | nM | 4.69 |