Assay Detail
Binding
CHEMBL768515
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Evaluated against recombinant human Protein kinase C alpha
26
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and protein kinase C inhibitory activities of acyclic balanol analogs that are highly selective for protein kinase C over protein kinase A.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 26 | 5.90 | 7.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL295806 | — | — | 2 | 7.52 |
| CHEMBL60254 | BALANOL | — | 1 | 7.52 |
| CHEMBL48636 | — | — | 1 | 7.40 |
| CHEMBL49354 | — | — | 1 | 7.17 |
| CHEMBL358264 | — | — | 1 | 6.96 |
| CHEMBL345767 | — | — | 1 | 6.68 |
| CHEMBL48988 | — | — | 1 | 6.66 |
| CHEMBL300422 | — | — | 1 | 6.58 |
| CHEMBL148745 | — | — | 1 | 6.39 |
| CHEMBL48665 | — | — | 1 | 5.85 |
| CHEMBL151822 | — | — | 1 | 5.72 |
| CHEMBL151800 | — | — | 1 | 5.72 |
| CHEMBL48546 | — | — | 1 | 5.66 |
| CHEMBL151823 | — | — | 1 | 5.50 |
| CHEMBL439996 | — | — | 1 | 5.48 |
| CHEMBL421790 | — | — | 1 | 5.40 |
| CHEMBL146846 | — | — | 1 | 5.21 |
| CHEMBL149313 | — | — | 1 | 5.11 |
| CHEMBL149873 | — | — | 1 | 4.96 |
| CHEMBL151731 | — | — | 1 | 4.75 |
| CHEMBL150264 | — | — | 1 | 4.75 |
| CHEMBL146847 | — | — | 1 | 4.75 |
| CHEMBL149604 | — | — | 1 | 4.64 |
| CHEMBL343362 | — | — | 1 | 4.35 |
| CHEMBL150422 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL295806 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL60254 | BALANOL | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL48636 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL49354 | — | IC50 | = | 67.0 | nM | 7.17 |
| CHEMBL358264 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL295806 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL345767 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL48988 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL300422 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL148745 | — | IC50 | = | 410.0 | nM | 6.39 |
| CHEMBL48665 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL151822 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL151800 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL48546 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL151823 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL439996 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL421790 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL146846 | — | IC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL149313 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL149873 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL151731 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL150264 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL146847 | — | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL149604 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL343362 | — | IC50 | = | 45000.0 | nM | 4.35 |
| CHEMBL150422 | — | IC50 | > | 50000.0 | nM | - |