Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL768517

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of Protein kinase C alpha expressed in Sf-9 cells
15
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Cell Type Sf-9
Confidence 9 — Direct single protein target
Curated By Expert

Target

Protein kinase C alpha type (CHEMBL299)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Increasing the cellular PKC inhibitory activity of balanol: A study of ester analogs
Crane HM, Menaldino DS, Erik Jagdmann G, Darges JW, Buben JA
Bioorg Med Chem Lett (1995) 5 : 2133 -2138
· DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 15 6.20 7.66

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL59828 1 7.66
CHEMBL52529 1 7.40
CHEMBL60254 BALANOL 1 7.13
CHEMBL67528 1 6.89
CHEMBL304175 1 6.80
CHEMBL66923 3 6.68
CHEMBL304626 1 6.60
CHEMBL66452 1 6.04
CHEMBL307543 1 5.66
CHEMBL66750 1 5.51
CHEMBL431568 1 5.33
CHEMBL302304 1 4.77
CHEMBL68418 1 4.72

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL59828 IC50 = 22.0 nM 7.66
CHEMBL52529 IC50 = 40.0 nM 7.40
CHEMBL60254 BALANOL IC50 = 74.0 nM 7.13
CHEMBL67528 IC50 = 130.0 nM 6.89
CHEMBL304175 IC50 = 160.0 nM 6.80
CHEMBL66923 IC50 = 210.0 nM 6.68
CHEMBL304626 IC50 = 250.0 nM 6.60
CHEMBL66923 IC50 = 320.0 nM 6.50
CHEMBL66452 IC50 = 920.0 nM 6.04
CHEMBL307543 IC50 = 2200.0 nM 5.66
CHEMBL66750 IC50 = 3100.0 nM 5.51
CHEMBL66923 IC50 = 4200.0 nM 5.38
CHEMBL431568 IC50 = 4700.0 nM 5.33
CHEMBL302304 IC50 = 17000.0 nM 4.77
CHEMBL68418 IC50 = 19000.0 nM 4.72