Assay Detail
Binding
CHEMBL768521
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In vitro inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assay
16
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The development of potent non-peptidic PTP-1B inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.58 | 7.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL9046 | — | — | 1 | 7.40 |
| CHEMBL267954 | — | — | 1 | 7.22 |
| CHEMBL266056 | — | — | 2 | 7.22 |
| CHEMBL263348 | — | — | 1 | 7.05 |
| CHEMBL8767 | — | — | 1 | 6.96 |
| CHEMBL8758 | — | — | 1 | 6.92 |
| CHEMBL276376 | — | — | 1 | 6.80 |
| CHEMBL8725 | — | — | 1 | 6.72 |
| CHEMBL9087 | — | — | 1 | 6.72 |
| CHEMBL428651 | — | — | 1 | 6.44 |
| CHEMBL9070 | — | — | 1 | 6.41 |
| CHEMBL8660 | — | — | 1 | 6.10 |
| CHEMBL267981 | — | — | 1 | 6.03 |
| CHEMBL267022 | — | — | 1 | 5.70 |
| CHEMBL9047 | — | — | 1 | 4.80 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL9046 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL267954 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL266056 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL263348 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL8767 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL8758 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL276376 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL8725 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL9087 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL266056 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL428651 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL9070 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL8660 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL267981 | — | IC50 | = | 940.0 | nM | 6.03 |
| CHEMBL267022 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL9047 | — | IC50 | = | 16000.0 | nM | 4.80 |