Assay Detail
Binding
CHEMBL768523
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibitory activity against Protein tyrosine phosphatase 1B (PTP1B) over-expressed in intact Sf9 cell assay
23
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Sf9 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.43 | 7.24 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL266753 | — | — | 4 | 7.24 |
| CHEMBL273474 | — | — | 1 | 7.21 |
| CHEMBL268903 | — | — | 1 | 7.08 |
| CHEMBL8662 | — | — | 1 | 7.06 |
| CHEMBL267048 | — | — | 1 | 6.92 |
| CHEMBL276647 | — | — | 1 | 6.92 |
| CHEMBL274435 | — | — | 1 | 6.92 |
| CHEMBL267488 | — | — | 1 | 6.80 |
| CHEMBL9473 | — | — | 1 | 6.72 |
| CHEMBL268526 | — | — | 1 | 6.66 |
| CHEMBL269166 | — | — | 1 | 6.62 |
| CHEMBL276648 | — | — | 1 | 6.43 |
| CHEMBL416145 | — | — | 1 | 6.34 |
| CHEMBL9321 | — | — | 1 | 6.19 |
| CHEMBL9252 | — | — | 1 | 6.03 |
| CHEMBL418703 | — | — | 1 | 5.92 |
| CHEMBL9339 | — | — | 1 | 5.80 |
| CHEMBL267759 | — | — | 1 | 5.80 |
| CHEMBL267245 | — | — | 1 | 5.77 |
| CHEMBL9374 | — | — | 1 | 5.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL266753 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL273474 | — | IC50 | = | 62.0 | nM | 7.21 |
| CHEMBL268903 | — | IC50 | = | 84.0 | nM | 7.08 |
| CHEMBL8662 | — | IC50 | = | 88.0 | nM | 7.06 |
| CHEMBL266753 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL267048 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL276647 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL274435 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL267488 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL9473 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL268526 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL269166 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL276648 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL416145 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL9321 | — | IC50 | = | 650.0 | nM | 6.19 |
| CHEMBL9252 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL418703 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL9339 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL267759 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL267245 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL266753 | — | IC50 | = | 1790.0 | nM | 5.75 |
| CHEMBL9374 | — | IC50 | = | 4070.0 | nM | 5.39 |
| CHEMBL266753 | — | IC50 | = | 5340.0 | nM | 5.27 |