Assay Detail
Binding
CHEMBL768525
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Inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) was determined in fluorescein diphosphate (FDP) assay
24
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure based design of a series of potent and selective non peptidic PTP-1B inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 7.45 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL269166 | — | — | 1 | 8.52 |
| CHEMBL267488 | — | — | 1 | 8.30 |
| CHEMBL266753 | — | — | 4 | 8.30 |
| CHEMBL268903 | — | — | 1 | 7.96 |
| CHEMBL268526 | — | — | 1 | 7.92 |
| CHEMBL267048 | — | — | 1 | 7.92 |
| CHEMBL276647 | — | — | 1 | 7.80 |
| CHEMBL274435 | — | — | 1 | 7.80 |
| CHEMBL8662 | — | — | 1 | 7.75 |
| CHEMBL9473 | — | — | 1 | 7.72 |
| CHEMBL273474 | — | — | 1 | 7.70 |
| CHEMBL418703 | — | — | 1 | 7.50 |
| CHEMBL267759 | — | — | 1 | 7.42 |
| CHEMBL9321 | — | — | 1 | 7.34 |
| CHEMBL416145 | — | — | 1 | 7.31 |
| CHEMBL9252 | — | — | 1 | 7.16 |
| CHEMBL276648 | — | — | 1 | 7.13 |
| CHEMBL9339 | — | — | 1 | 7.05 |
| CHEMBL9374 | — | — | 1 | 7.01 |
| CHEMBL267245 | — | — | 1 | 6.62 |
| CHEMBL9363 | — | — | 1 | 5.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL269166 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL266753 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL267488 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL266753 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL268903 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL267048 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL268526 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL276647 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL274435 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL8662 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL9473 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL273474 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL418703 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL267759 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL9321 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL416145 | — | IC50 | = | 49.0 | nM | 7.31 |
| CHEMBL9252 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL276648 | — | IC50 | = | 74.0 | nM | 7.13 |
| CHEMBL9339 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL9374 | — | IC50 | = | 98.0 | nM | 7.01 |
| CHEMBL266753 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL267245 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL266753 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL9363 | — | IC50 | = | 8040.0 | nM | 5.09 |