Assay Detail
Binding
CHEMBL768529
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Binding affinity for Protein-tyrosine phosphatase 1B
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Tyrosine-protein phosphatase non-receptor type 1 (CHEMBL335) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Fragment-based drug discovery.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.73 | 7.75 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL116605 | — | — | 1 | 7.75 |
| CHEMBL324968 | — | — | 1 | 7.66 |
| CHEMBL117699 | — | — | 1 | 7.38 |
| CHEMBL303333 | — | — | 1 | 5.96 |
| CHEMBL55799 | — | — | 1 | 5.92 |
| CHEMBL117869 | — | — | 1 | 5.16 |
| CHEMBL64934 | — | — | 1 | 4.41 |
| CHEMBL333158 | — | — | 1 | 3.83 |
| CHEMBL65459 | — | — | 1 | 3.53 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL116605 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL324968 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL117699 | — | Ki | = | 42.0 | nM | 7.38 |
| CHEMBL303333 | — | Ki | = | 1100.0 | nM | 5.96 |
| CHEMBL55799 | — | Ki | = | 1200.0 | nM | 5.92 |
| CHEMBL117869 | — | Ki | = | 6900.0 | nM | 5.16 |
| CHEMBL64934 | — | Ki | = | 39000.0 | nM | 4.41 |
| CHEMBL333158 | — | Ki | = | 148000.0 | nM | 3.83 |
| CHEMBL65459 | — | Ki | = | 293000.0 | nM | 3.53 |