Assay Detail
Binding
CHEMBL768586
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Inhibition against prostaglandin G/H synthase 2 from mouse resident macrophages
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1,3-Diaryl-4,5,6,7-tetrahydro-2H-isoindole derivatives: a new series of potent and selective COX-2 inhibitors in which a sulfonyl group is not a structural requisite.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 39 | 8.05 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL140167 | — | — | 1 | 9.22 |
| CHEMBL142650 | — | — | 1 | 9.15 |
| CHEMBL143776 | — | — | 1 | 8.96 |
| CHEMBL344085 | — | — | 1 | 8.82 |
| CHEMBL343701 | — | — | 1 | 8.80 |
| CHEMBL140991 | — | — | 1 | 8.78 |
| CHEMBL441663 | — | — | 1 | 8.77 |
| CHEMBL335371 | — | — | 1 | 8.74 |
| CHEMBL341878 | — | — | 1 | 8.59 |
| CHEMBL142038 | — | — | 1 | 8.54 |
| CHEMBL343339 | — | — | 1 | 8.51 |
| CHEMBL140804 | — | — | 1 | 8.48 |
| CHEMBL139721 | — | — | 1 | 8.35 |
| CHEMBL140726 | — | — | 1 | 8.30 |
| CHEMBL341652 | — | — | 1 | 8.00 |
| CHEMBL141298 | — | — | 1 | 8.00 |
| CHEMBL143653 | — | — | 1 | 7.96 |
| CHEMBL343311 | — | — | 1 | 7.84 |
| CHEMBL140876 | — | — | 1 | 7.67 |
| CHEMBL344837 | — | — | 1 | 7.54 |
| CHEMBL140092 | — | — | 1 | 7.49 |
| CHEMBL140533 | — | — | 1 | 7.45 |
| CHEMBL139591 | — | — | 1 | 7.38 |
| CHEMBL143523 | — | — | 1 | 7.30 |
| CHEMBL140171 | — | — | 1 | 6.30 |
| CHEMBL141312 | — | — | 1 | 6.30 |
| CHEMBL344841 | — | — | 1 | 6.16 |
| CHEMBL538792 | — | — | 1 | - |
| CHEMBL544620 | — | — | 1 | - |
| CHEMBL337601 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL140167 | — | IC50 | = | 0.6 | nM | 9.22 |
| CHEMBL142650 | — | IC50 | = | 0.7 | nM | 9.15 |
| CHEMBL143776 | — | IC50 | = | 1.1 | nM | 8.96 |
| CHEMBL344085 | — | IC50 | = | 1.5 | nM | 8.82 |
| CHEMBL343701 | — | IC50 | = | 1.6 | nM | 8.80 |
| CHEMBL140991 | — | IC50 | = | 1.67 | nM | 8.78 |
| CHEMBL441663 | — | IC50 | = | 1.7 | nM | 8.77 |
| CHEMBL335371 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL341878 | — | IC50 | = | 2.6 | nM | 8.59 |
| CHEMBL142038 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL343339 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL140804 | — | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL139721 | — | IC50 | = | 4.5 | nM | 8.35 |
| CHEMBL140726 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL141298 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL341652 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL143653 | — | IC50 | = | 10.9 | nM | 7.96 |
| CHEMBL343311 | — | IC50 | = | 14.5 | nM | 7.84 |
| CHEMBL140876 | — | IC50 | = | 21.3 | nM | 7.67 |
| CHEMBL344837 | — | IC50 | = | 28.7 | nM | 7.54 |
| CHEMBL140092 | — | IC50 | = | 32.4 | nM | 7.49 |
| CHEMBL140533 | — | IC50 | = | 35.6 | nM | 7.45 |
| CHEMBL139591 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL143523 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL140171 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL141312 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL344841 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL143573 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL552904 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL343280 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL344381 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL554786 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL140206 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL345038 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL445127 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL343716 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL337601 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL544620 | — | IC50 | > | 100.0 | nM | - |
| CHEMBL538792 | — | IC50 | > | 100.0 | nM | - |