Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL768604

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
In vitro inhibition of U 46619 induced aggregation of washed platelets
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 1 — Organism
Curated By Expert

Target

Homo sapiens (CHEMBL372)
Type ORGANISM
Organism Homo sapiens

Publication

Thromboxane receptor antagonism combined with thromboxane synthase inhibition. 4. 8-[[(4-Chlorophenyl)sulfonyl]amino]-4-(3-(3-pyridinyl) propyl)octanoic acid and analogs.
Bhagwat SS, Gude C, Boswell C, Contardo N, Cohen DS, Dotson R, Mathis J, Lee W, Furness P, Zoganas H.
J Med Chem (1992) 35 : 4373 -4383
PubMed 1447738 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 25 7.02 8.22

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL341686 1 8.22
CHEMBL137402 1 8.22
CHEMBL63904 1 7.89
CHEMBL343535 1 7.82
CHEMBL134365 1 7.75
CHEMBL65414 1 7.72
CHEMBL138743 1 7.66
CHEMBL136880 1 7.57
CHEMBL137505 1 7.46
CHEMBL136934 1 7.28
CHEMBL435590 1 7.24
CHEMBL134686 1 7.16
CHEMBL136762 1 6.97
CHEMBL345105 1 6.70
CHEMBL344457 1 6.66
CHEMBL139372 1 6.64
CHEMBL136738 1 6.62
CHEMBL136371 1 6.30
CHEMBL137187 1 6.23
CHEMBL134580 1 6.01
CHEMBL280728 RIDOGREL 2.0 1 5.89
CHEMBL136918 1 5.82
CHEMBL136130 1 5.63
CHEMBL136149 1 -
CHEMBL138328 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL341686 IC50 = 6.0 nM 8.22
CHEMBL137402 IC50 = 6.0 nM 8.22
CHEMBL63904 IC50 = 13.0 nM 7.89
CHEMBL343535 IC50 = 15.0 nM 7.82
CHEMBL134365 IC50 = 18.0 nM 7.75
CHEMBL65414 IC50 = 19.0 nM 7.72
CHEMBL138743 IC50 = 22.0 nM 7.66
CHEMBL136880 IC50 = 27.0 nM 7.57
CHEMBL137505 IC50 = 35.0 nM 7.46
CHEMBL136934 IC50 = 53.0 nM 7.28
CHEMBL435590 IC50 = 58.0 nM 7.24
CHEMBL134686 IC50 = 70.0 nM 7.16
CHEMBL136762 IC50 = 108.0 nM 6.97
CHEMBL345105 IC50 = 200.0 nM 6.70
CHEMBL344457 IC50 = 220.0 nM 6.66
CHEMBL139372 IC50 = 230.0 nM 6.64
CHEMBL136738 IC50 = 240.0 nM 6.62
CHEMBL136371 IC50 = 500.0 nM 6.30
CHEMBL137187 IC50 = 590.0 nM 6.23
CHEMBL134580 IC50 = 980.0 nM 6.01
CHEMBL280728 RIDOGREL IC50 = 1280.0 nM 5.89
CHEMBL136918 IC50 = 1520.0 nM 5.82
CHEMBL136130 IC50 = 2360.0 nM 5.63
CHEMBL136149 IC50 > 10000.0 nM -
CHEMBL138328 IC50 > 10000.0 nM -