Assay Detail
Binding
CHEMBL768607
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Inhibitory activity against phosphodiesterase 4 carried out in the cytosol of human neutrophils
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Novel selective phosphodiesterase (PDE4) inhibitors. 4. Resolution, absolute configuration, and PDE4 inhibitory activity of cis-tetra- and cis-hexahydrophthalazinones.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 28 | 7.25 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL313982 | — | — | 1 | 9.30 |
| CHEMBL315565 | — | — | 1 | 9.20 |
| CHEMBL314938 | — | — | 1 | 8.50 |
| CHEMBL312868 | — | — | 1 | 8.30 |
| CHEMBL87412 | — | — | 1 | 8.20 |
| CHEMBL316016 | — | — | 1 | 8.00 |
| CHEMBL315934 | — | — | 1 | 8.00 |
| CHEMBL85753 | — | — | 1 | 7.80 |
| CHEMBL86145 | — | — | 1 | 7.70 |
| CHEMBL32442 | CDP840 | — | 1 | 7.70 |
| CHEMBL85895 | — | — | 1 | 7.40 |
| CHEMBL440878 | — | — | 1 | 7.30 |
| CHEMBL315248 | — | — | 1 | 7.30 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 7.30 |
| CHEMBL312666 | — | — | 1 | 7.10 |
| CHEMBL312799 | — | — | 1 | 7.10 |
| CHEMBL511115 | CILOMILAST | 3.0 | 1 | 7.00 |
| CHEMBL313041 | — | — | 1 | 7.00 |
| CHEMBL85424 | — | — | 1 | 6.90 |
| CHEMBL86158 | — | — | 1 | 6.90 |
| CHEMBL85197 | — | — | 1 | 6.80 |
| CHEMBL83813 | — | — | 1 | 6.70 |
| CHEMBL312212 | — | — | 1 | 6.60 |
| CHEMBL82318 | — | — | 1 | 6.40 |
| CHEMBL312101 | — | — | 1 | 6.10 |
| CHEMBL81896 | — | — | 1 | 5.80 |
| CHEMBL315264 | — | — | 1 | 5.60 |
| CHEMBL84779 | — | — | 1 | 5.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL313982 | — | IC50 | = | 0.5012 | nM | 9.30 |
| CHEMBL315565 | — | IC50 | = | 0.631 | nM | 9.20 |
| CHEMBL314938 | — | IC50 | = | 3.162 | nM | 8.50 |
| CHEMBL312868 | — | IC50 | = | 5.012 | nM | 8.30 |
| CHEMBL87412 | — | IC50 | = | 6.31 | nM | 8.20 |
| CHEMBL316016 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL315934 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL85753 | — | IC50 | = | 15.85 | nM | 7.80 |
| CHEMBL86145 | — | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL32442 | CDP840 | IC50 | = | 19.95 | nM | 7.70 |
| CHEMBL85895 | — | IC50 | = | 39.81 | nM | 7.40 |
| CHEMBL440878 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL315248 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL312666 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL312799 | — | IC50 | = | 79.43 | nM | 7.10 |
| CHEMBL511115 | CILOMILAST | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL313041 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL85424 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL86158 | — | IC50 | = | 125.89 | nM | 6.90 |
| CHEMBL85197 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL83813 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL312212 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL82318 | — | IC50 | = | 398.11 | nM | 6.40 |
| CHEMBL312101 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL81896 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL315264 | — | IC50 | = | 2511.89 | nM | 5.60 |
| CHEMBL84779 | — | IC50 | = | 7943.28 | nM | 5.10 |