Compound Detail
CHEMBL315934
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Basic Information
| ChEMBL ID | CHEMBL315934 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OVLZKANHBRXYRB-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
462.6
MW (Da)
4.99
ALogP
6
HBA
0
HBD
77.4
PSA (Ų)
0.41
QED
0
Ro5 Violations
8
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphodiesterase 4 CHEMBL2093863 | IC50 | 8.0 | 8.0 | 10.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphodiesterase 4 | IC50 | = | 10.0 | nM | 8.0 | Inhibitory activity against phosphodiesterase 4 carried out in the cytosol of hu... | 12036361 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12036361 | 10.1021/jm0110338 | Phosphodiesterase 4 | 1 |
| 12036361 | 10.1021/jm0110338 | Mus musculus | 1 |
Data from ChEMBL 36 via Core Engine