Assay Detail
Binding
CHEMBL768662
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Inhibition of Ca++ calmodulin dependent-PDE 1 from porcine aorta
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.26 | 5.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL302299 | — | — | 1 | 5.26 |
| CHEMBL304927 | — | — | 1 | - |
| CHEMBL67276 | — | — | 1 | - |
| CHEMBL66620 | — | — | 1 | - |
| CHEMBL67243 | — | — | 1 | - |
| CHEMBL66323 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL302299 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL304927 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL67276 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL66620 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL67243 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL66323 | — | IC50 | > | 100000.0 | nM | - |