Assay Detail
Functional
CHEMBL768678
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro for inhibition of 5-HETE production in isolated rat polymorphonuclear leukocytes (PMNs)
24
Total Activities
24
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and antiallergic activity of a novel series of 5-lipoxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 24 | 5.02 | 5.97 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75651 | — | — | 1 | 5.97 |
| CHEMBL77872 | — | — | 1 | 5.96 |
| CHEMBL73936 | — | — | 1 | 5.80 |
| CHEMBL76884 | — | — | 1 | 5.70 |
| CHEMBL308573 | — | — | 1 | 5.56 |
| CHEMBL78007 | — | — | 1 | 5.46 |
| CHEMBL75123 | — | — | 1 | 5.43 |
| CHEMBL312747 | — | — | 1 | 5.34 |
| CHEMBL310232 | — | — | 1 | 5.27 |
| CHEMBL309048 | — | — | 1 | 5.25 |
| CHEMBL74615 | — | — | 1 | 5.11 |
| CHEMBL307264 | — | — | 1 | 4.92 |
| CHEMBL306979 | — | — | 1 | 4.85 |
| CHEMBL77631 | — | — | 1 | 4.68 |
| CHEMBL77048 | — | — | 1 | 4.66 |
| CHEMBL75830 | — | — | 1 | 4.60 |
| CHEMBL78210 | — | — | 1 | 4.59 |
| CHEMBL74841 | — | — | 1 | 4.54 |
| CHEMBL307575 | — | — | 1 | 4.49 |
| CHEMBL77704 | — | — | 1 | 4.44 |
| CHEMBL77722 | — | — | 1 | 4.41 |
| CHEMBL162358 | TOMELUKAST | 2.0 | 1 | 4.39 |
| CHEMBL78026 | — | — | 1 | 4.12 |
| CHEMBL77668 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75651 | — | IC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL77872 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL73936 | — | IC50 | = | 1590.0 | nM | 5.80 |
| CHEMBL76884 | — | IC50 | = | 2010.0 | nM | 5.70 |
| CHEMBL308573 | — | IC50 | = | 2730.0 | nM | 5.56 |
| CHEMBL78007 | — | IC50 | = | 3440.0 | nM | 5.46 |
| CHEMBL75123 | — | IC50 | = | 3710.0 | nM | 5.43 |
| CHEMBL312747 | — | IC50 | = | 4540.0 | nM | 5.34 |
| CHEMBL310232 | — | IC50 | = | 5350.0 | nM | 5.27 |
| CHEMBL309048 | — | IC50 | = | 5600.0 | nM | 5.25 |
| CHEMBL74615 | — | IC50 | = | 7740.0 | nM | 5.11 |
| CHEMBL307264 | — | IC50 | = | 12100.0 | nM | 4.92 |
| CHEMBL306979 | — | IC50 | = | 14200.0 | nM | 4.85 |
| CHEMBL77631 | — | IC50 | = | 20800.0 | nM | 4.68 |
| CHEMBL77048 | — | IC50 | = | 22000.0 | nM | 4.66 |
| CHEMBL75830 | — | IC50 | = | 25100.0 | nM | 4.60 |
| CHEMBL78210 | — | IC50 | = | 25530.0 | nM | 4.59 |
| CHEMBL74841 | — | IC50 | = | 28500.0 | nM | 4.54 |
| CHEMBL307575 | — | IC50 | = | 32670.0 | nM | 4.49 |
| CHEMBL77704 | — | IC50 | = | 36300.0 | nM | 4.44 |
| CHEMBL77722 | — | IC50 | = | 38560.0 | nM | 4.41 |
| CHEMBL162358 | TOMELUKAST | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL78026 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL77668 | — | IC50 | > | 50000.0 | nM | - |