Assay Detail
Functional
CHEMBL768679
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro for inhibition of LTB4 (leukotriene B4) production in isolated rat polymorphonuclear leukocytes (PMNs).
19
Total Activities
19
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Polyunsaturated fatty acid 5-lipoxygenase (CHEMBL312) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and antiallergic activity of a novel series of 5-lipoxygenase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 19 | 4.94 | 5.88 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL75651 | — | — | 1 | 5.88 |
| CHEMBL73936 | — | — | 1 | 5.77 |
| CHEMBL76884 | — | — | 1 | 5.65 |
| CHEMBL308573 | — | — | 1 | 5.50 |
| CHEMBL75123 | — | — | 1 | 5.41 |
| CHEMBL78007 | — | — | 1 | 5.38 |
| CHEMBL312747 | — | — | 1 | 5.26 |
| CHEMBL309048 | — | — | 1 | 5.15 |
| CHEMBL306979 | — | — | 1 | 4.93 |
| CHEMBL307264 | — | — | 1 | 4.70 |
| CHEMBL310232 | — | — | 1 | 4.69 |
| CHEMBL162358 | TOMELUKAST | 2.0 | 1 | 4.67 |
| CHEMBL78210 | — | — | 1 | 4.65 |
| CHEMBL77631 | — | — | 1 | 4.56 |
| CHEMBL77704 | — | — | 1 | 4.46 |
| CHEMBL307575 | — | — | 1 | 4.41 |
| CHEMBL75830 | — | — | 1 | 4.40 |
| CHEMBL77722 | — | — | 1 | 4.21 |
| CHEMBL78026 | — | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL75651 | — | IC50 | = | 1330.0 | nM | 5.88 |
| CHEMBL73936 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL76884 | — | IC50 | = | 2240.0 | nM | 5.65 |
| CHEMBL308573 | — | IC50 | = | 3140.0 | nM | 5.50 |
| CHEMBL75123 | — | IC50 | = | 3870.0 | nM | 5.41 |
| CHEMBL78007 | — | IC50 | = | 4140.0 | nM | 5.38 |
| CHEMBL312747 | — | IC50 | = | 5500.0 | nM | 5.26 |
| CHEMBL309048 | — | IC50 | = | 7090.0 | nM | 5.15 |
| CHEMBL306979 | — | IC50 | = | 11700.0 | nM | 4.93 |
| CHEMBL307264 | — | IC50 | = | 19900.0 | nM | 4.70 |
| CHEMBL310232 | — | IC50 | = | 20360.0 | nM | 4.69 |
| CHEMBL162358 | TOMELUKAST | IC50 | = | 21600.0 | nM | 4.67 |
| CHEMBL78210 | — | IC50 | = | 22520.0 | nM | 4.65 |
| CHEMBL77631 | — | IC50 | = | 27800.0 | nM | 4.56 |
| CHEMBL77704 | — | IC50 | = | 34700.0 | nM | 4.46 |
| CHEMBL307575 | — | IC50 | = | 39340.0 | nM | 4.41 |
| CHEMBL75830 | — | IC50 | = | 39500.0 | nM | 4.40 |
| CHEMBL77722 | — | IC50 | = | 62070.0 | nM | 4.21 |
| CHEMBL78026 | — | IC50 | = | 70000.0 | nM | 4.16 |