Assay Detail
Binding
CHEMBL768695
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Inhibition of human IKs-channel expressed in Xenopus oocytes
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Oocyte |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) (CHEMBL2221347) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and activity of novel and selective I(Ks)-channel blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.10 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL124454 | — | — | 1 | 7.30 |
| CHEMBL298475 | — | — | 1 | 6.92 |
| CHEMBL124308 | — | — | 1 | 6.70 |
| CHEMBL340910 | — | — | 1 | 6.62 |
| CHEMBL125307 | — | — | 1 | 6.60 |
| CHEMBL127885 | — | — | 1 | 6.40 |
| CHEMBL340236 | — | — | 1 | 6.36 |
| CHEMBL340025 | — | — | 1 | 6.16 |
| CHEMBL124810 | — | — | 1 | 6.05 |
| CHEMBL338171 | — | — | 1 | 5.96 |
| CHEMBL127435 | — | — | 1 | 5.92 |
| CHEMBL124812 | — | — | 1 | 5.66 |
| CHEMBL125259 | — | — | 1 | 5.51 |
| CHEMBL338273 | — | — | 1 | 5.16 |
| CHEMBL330993 | — | — | 1 | 4.24 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL124454 | — | IC50 | = | 50.0 | nM | 7.30 |
| CHEMBL298475 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL124308 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL340910 | — | IC50 | = | 240.0 | nM | 6.62 |
| CHEMBL125307 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL127885 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL340236 | — | IC50 | = | 440.0 | nM | 6.36 |
| CHEMBL340025 | — | IC50 | = | 700.0 | nM | 6.16 |
| CHEMBL124810 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL338171 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL127435 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL124812 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL125259 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL338273 | — | IC50 | = | 6900.0 | nM | 5.16 |
| CHEMBL330993 | — | IC50 | = | 58000.0 | nM | 4.24 |