Assay Detail
Binding
CHEMBL768696
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Inhibition of human IKs-channel expressed in Xenopus oocytes,(Experiment 1)
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | Oocyte |
| Confidence | 6 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) (CHEMBL2221347) ↗| Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
Publication
Synthesis and activity of novel and selective I(Ks)-channel blockers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.83 | 5.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL434045 | — | — | 1 | 5.30 |
| CHEMBL44297 | — | — | 1 | 4.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL434045 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL44297 | — | IC50 | = | 44500.0 | nM | 4.35 |