Assay Detail
Binding
CHEMBL768737
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Concentration required to inhibit human prostaglandin G/H synthase 1 (COX-1) by 50%
96
Total Activities
96
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 96 | 5.02 | 7.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 7.00 |
| CHEMBL298476 | — | — | 1 | 6.24 |
| CHEMBL296447 | — | — | 1 | 5.96 |
| CHEMBL296078 | — | — | 1 | 5.81 |
| CHEMBL45192 | — | — | 1 | 5.80 |
| CHEMBL46623 | — | — | 1 | 5.72 |
| CHEMBL45197 | — | — | 1 | 5.68 |
| CHEMBL47147 | — | — | 1 | 5.56 |
| CHEMBL264300 | — | — | 1 | 5.52 |
| CHEMBL42398 | — | — | 1 | 5.50 |
| CHEMBL42674 | — | — | 1 | 5.45 |
| CHEMBL296662 | — | — | 1 | 5.42 |
| CHEMBL46584 | — | — | 1 | 5.35 |
| CHEMBL297108 | — | — | 1 | 5.34 |
| CHEMBL42996 | — | — | 1 | 5.30 |
| CHEMBL298313 | — | — | 1 | 5.24 |
| CHEMBL298269 | — | — | 1 | 5.21 |
| CHEMBL290945 | — | — | 1 | 5.11 |
| CHEMBL294967 | — | — | 1 | 5.09 |
| CHEMBL289561 | — | — | 1 | 5.07 |
| CHEMBL296673 | — | — | 1 | 4.92 |
| CHEMBL44977 | — | — | 1 | 4.77 |
| CHEMBL296984 | — | — | 1 | 4.71 |
| CHEMBL44926 | — | — | 1 | 4.65 |
| CHEMBL44516 | — | — | 1 | 4.64 |
| CHEMBL297799 | — | — | 1 | 4.62 |
| CHEMBL42561 | — | — | 1 | 4.58 |
| CHEMBL296571 | — | — | 1 | 4.53 |
| CHEMBL43493 | — | — | 1 | 4.52 |
| CHEMBL43317 | — | — | 1 | 4.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL298476 | — | IC50 | = | 570.0 | nM | 6.24 |
| CHEMBL296447 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL296078 | — | IC50 | = | 1560.0 | nM | 5.81 |
| CHEMBL45192 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL46623 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL45197 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL47147 | — | IC50 | = | 2740.0 | nM | 5.56 |
| CHEMBL264300 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL42398 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL42674 | — | IC50 | = | 3540.0 | nM | 5.45 |
| CHEMBL296662 | — | IC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL46584 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL297108 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL42996 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL298313 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL298269 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL290945 | — | IC50 | = | 7840.0 | nM | 5.11 |
| CHEMBL294967 | — | IC50 | = | 8200.0 | nM | 5.09 |
| CHEMBL289561 | — | IC50 | = | 8600.0 | nM | 5.07 |
| CHEMBL296673 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL44977 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL296984 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL44926 | — | IC50 | = | 22300.0 | nM | 4.65 |
| CHEMBL44516 | — | IC50 | = | 23000.0 | nM | 4.64 |
| CHEMBL297799 | — | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL42561 | — | IC50 | = | 26000.0 | nM | 4.58 |
| CHEMBL296571 | — | IC50 | = | 29800.0 | nM | 4.53 |
| CHEMBL43493 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL43317 | — | IC50 | = | 35000.0 | nM | 4.46 |
| CHEMBL432112 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL44829 | — | IC50 | = | 42200.0 | nM | 4.38 |
| CHEMBL42651 | — | IC50 | = | 49000.0 | nM | 4.31 |
| CHEMBL43103 | — | IC50 | = | 53500.0 | nM | 4.27 |
| CHEMBL43640 | — | IC50 | = | 67000.0 | nM | 4.17 |
| CHEMBL43672 | — | IC50 | = | 67700.0 | nM | 4.17 |
| CHEMBL417170 | — | IC50 | = | 82000.0 | nM | 4.09 |
| CHEMBL46712 | — | IC50 | = | 90000.0 | nM | 4.05 |
| CHEMBL43331 | — | IC50 | = | 91000.0 | nM | 4.04 |
| CHEMBL44468 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL414162 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL295752 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL42074 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL45090 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL42223 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL42408 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL42225 | — | IC50 | = | 723000.0 | nM | - |
| CHEMBL42119 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL295654 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL298296 | — | IC50 | > | 100000.0 | nM | - |