Assay Detail
Binding
CHEMBL768740
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IC50 against Prostaglandin G/H synthase 1 from human platelet rich plasma
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Tissue | Plasma |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.73 | 6.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL278246 | — | — | 1 | 6.23 |
| CHEMBL15945 | — | — | 1 | 6.00 |
| CHEMBL48568 | — | — | 1 | 5.92 |
| CHEMBL15904 | — | — | 1 | 5.82 |
| CHEMBL15781 | — | — | 1 | 5.36 |
| CHEMBL49008 | — | — | 1 | 5.03 |
| CHEMBL277515 | — | — | 1 | - |
| CHEMBL277124 | — | — | 1 | - |
| CHEMBL274990 | SC-58125 | — | 1 | - |
| CHEMBL280471 | — | — | 1 | - |
| CHEMBL295739 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL278246 | — | IC50 | = | 590.0 | nM | 6.23 |
| CHEMBL15945 | — | IC50 | = | 990.0 | nM | 6.00 |
| CHEMBL48568 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL15904 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL15781 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL49008 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL277515 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL277124 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL274990 | SC-58125 | IC50 | > | 20000.0 | nM | - |
| CHEMBL280471 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL295739 | — | IC50 | > | 20000.0 | nM | - |