Assay Detail
Binding
CHEMBL768746
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against human Prostaglandin G/H synthase 1 (COX-1) in U-937 cells
88
Total Activities
88
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | U-937 |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 88 | 5.63 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 8.70 |
| CHEMBL325894 | — | — | 1 | 6.96 |
| CHEMBL117528 | — | — | 1 | 6.96 |
| CHEMBL419407 | — | — | 1 | 6.22 |
| CHEMBL115410 | — | — | 1 | 6.05 |
| CHEMBL115979 | — | — | 1 | 5.92 |
| CHEMBL333651 | — | — | 1 | 5.89 |
| CHEMBL324048 | — | — | 1 | 5.72 |
| CHEMBL324312 | — | — | 1 | 5.66 |
| CHEMBL332251 | — | — | 1 | 5.57 |
| CHEMBL326270 | — | — | 1 | 5.51 |
| CHEMBL435381 | CIMICOXIB | 2.0 | 1 | 5.48 |
| CHEMBL326291 | — | — | 1 | 5.40 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.29 |
| CHEMBL118064 | — | — | 1 | 5.29 |
| CHEMBL324826 | — | — | 1 | 5.05 |
| CHEMBL118962 | — | — | 1 | 4.97 |
| CHEMBL117917 | — | — | 1 | 4.81 |
| CHEMBL115752 | — | — | 1 | 4.62 |
| CHEMBL117947 | — | — | 1 | 4.12 |
| CHEMBL117650 | — | — | 1 | 4.00 |
| CHEMBL324042 | — | — | 1 | - |
| CHEMBL118067 | — | — | 1 | - |
| CHEMBL115905 | — | — | 1 | - |
| CHEMBL117306 | — | — | 1 | - |
| CHEMBL118936 | — | — | 1 | - |
| CHEMBL333755 | — | — | 1 | - |
| CHEMBL119076 | — | — | 1 | - |
| CHEMBL324472 | — | — | 1 | - |
| CHEMBL114783 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL6 | INDOMETHACIN | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL325894 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL117528 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL419407 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL115410 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL115979 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL333651 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL324048 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL324312 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL332251 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL326270 | — | IC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL435381 | CIMICOXIB | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL326291 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL118 | CELECOXIB | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL118064 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL324826 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL118962 | — | IC50 | = | 10800.0 | nM | 4.97 |
| CHEMBL117917 | — | IC50 | = | 15500.0 | nM | 4.81 |
| CHEMBL115752 | — | IC50 | = | 23800.0 | nM | 4.62 |
| CHEMBL117947 | — | IC50 | = | 76000.0 | nM | 4.12 |
| CHEMBL117650 | — | IC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL117547 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL116016 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL116253 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL331135 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL116498 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL117946 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL119089 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL117855 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL325492 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL116848 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL333505 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL326335 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL324957 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL116683 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL119853 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL324923 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL117862 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL324825 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL116933 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL325297 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL114783 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL324472 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL119076 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL333755 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL118936 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL117306 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL115905 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL118067 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL324042 | — | IC50 | > | 10000.0 | nM | - |