Assay Detail
Binding
CHEMBL768750
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro inhibitory activity against human whole blood Prostaglandin G/H synthase 1
9
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Autocuration |
Publication
The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 5.26 | 6.82 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL139 | DICLOFENAC | 4.0 | 1 | 6.82 |
| CHEMBL6 | INDOMETHACIN | 4.0 | 1 | 6.70 |
| CHEMBL431546 | — | — | 1 | 5.24 |
| CHEMBL118 | CELECOXIB | 4.0 | 1 | 5.20 |
| CHEMBL51434 | — | — | 1 | 5.00 |
| CHEMBL18264 | — | — | 1 | 4.89 |
| CHEMBL122 | ROFECOXIB | 4.0 | 2 | 4.72 |
| CHEMBL52285 | — | — | 1 | 4.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL139 | DICLOFENAC | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL6 | INDOMETHACIN | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL431546 | — | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL118 | CELECOXIB | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL51434 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL18264 | — | IC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL122 | ROFECOXIB | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL52285 | — | IC50 | = | 86000.0 | nM | 4.07 |