Assay Detail
Functional
CHEMBL768814
Review assay metadata, readout intent, target linkage, and publication context from the same page.
In vitro antagonist activity against human progesterone receptor isoform B(hPR-B) in mammalian(CV-1) cells
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Expert |
Publication
Discovery and preliminary SAR studies of a novel, nonsteroidal progesterone receptor antagonist pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 7.44 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 9.52 |
| CHEMBL1908373 | ONAPRISTONE | 2.0 | 1 | 8.66 |
| CHEMBL117465 | — | — | 1 | 7.52 |
| CHEMBL115904 | — | — | 1 | 7.42 |
| CHEMBL93027 | — | — | 1 | 7.38 |
| CHEMBL117308 | — | — | 1 | 7.16 |
| CHEMBL117586 | — | — | 1 | 7.10 |
| CHEMBL117585 | — | — | 1 | 6.12 |
| CHEMBL93463 | — | — | 1 | 6.11 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL1908373 | ONAPRISTONE | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL117465 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL115904 | — | IC50 | = | 38.0 | nM | 7.42 |
| CHEMBL93027 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL117308 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL117586 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL117585 | — | IC50 | = | 750.0 | nM | 6.12 |
| CHEMBL93463 | — | IC50 | = | 783.0 | nM | 6.11 |