Assay Detail
Binding
CHEMBL768822
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Inhibition of human progesterone receptor activation in T47D human breast cancer cell.
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | T47D |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Publication
Development of progesterone receptor antagonists from 1,2-dihydrochromeno[3,4-f]quinoline agonist pharmacophore.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 6.76 | 8.48 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1908373 | ONAPRISTONE | 2.0 | 1 | 8.48 |
| CHEMBL1276308 | MIFEPRISTONE | 4.0 | 1 | 8.48 |
| CHEMBL294116 | — | — | 1 | 7.00 |
| CHEMBL293409 | — | — | 1 | 6.98 |
| CHEMBL67362 | — | — | 1 | 6.86 |
| CHEMBL62227 | — | — | 1 | 6.83 |
| CHEMBL64294 | — | — | 1 | 6.82 |
| CHEMBL65522 | — | — | 1 | 6.73 |
| CHEMBL63788 | — | — | 1 | 6.66 |
| CHEMBL65079 | — | — | 1 | 6.47 |
| CHEMBL62798 | — | — | 1 | 6.43 |
| CHEMBL63610 | — | — | 1 | 6.43 |
| CHEMBL62761 | — | — | 1 | 6.34 |
| CHEMBL65380 | — | — | 1 | 6.32 |
| CHEMBL63870 | — | — | 1 | 6.31 |
| CHEMBL65054 | — | — | 1 | 6.30 |
| CHEMBL62714 | — | — | 1 | 6.11 |
| CHEMBL65307 | — | — | 1 | 6.09 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1908373 | ONAPRISTONE | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL1276308 | MIFEPRISTONE | IC50 | = | 3.3 | nM | 8.48 |
| CHEMBL294116 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL293409 | — | IC50 | = | 104.0 | nM | 6.98 |
| CHEMBL67362 | — | IC50 | = | 138.0 | nM | 6.86 |
| CHEMBL62227 | — | IC50 | = | 149.0 | nM | 6.83 |
| CHEMBL64294 | — | IC50 | = | 152.0 | nM | 6.82 |
| CHEMBL65522 | — | IC50 | = | 187.0 | nM | 6.73 |
| CHEMBL63788 | — | IC50 | = | 217.0 | nM | 6.66 |
| CHEMBL65079 | — | IC50 | = | 335.0 | nM | 6.47 |
| CHEMBL62798 | — | IC50 | = | 374.0 | nM | 6.43 |
| CHEMBL63610 | — | IC50 | = | 368.0 | nM | 6.43 |
| CHEMBL62761 | — | IC50 | = | 461.0 | nM | 6.34 |
| CHEMBL65380 | — | IC50 | = | 483.0 | nM | 6.32 |
| CHEMBL63870 | — | IC50 | = | 485.0 | nM | 6.31 |
| CHEMBL65054 | — | IC50 | = | 499.0 | nM | 6.30 |
| CHEMBL62714 | — | IC50 | = | 782.0 | nM | 6.11 |
| CHEMBL65307 | — | IC50 | = | 811.0 | nM | 6.09 |